Advances in studies on regulating effects of Wnt/β-catenin signaling pathway on neurovascular unit after cerebral Ischemia and related medicine
10.3969/j.issn.1001-1978.2016.03.003
- VernacularTitle:Wnt/β-catenin信号通路参与脑缺血后神经血管单元调控及相关药物的研究进展
- Author:
Jing WEN
;
Jian WANG
;
Shilan LUO
;
Wan PENG
;
Yimi REN
- Publication Type:Journal Article
- Keywords:
Wnt/β-catenin signaling pathway;
ischemic stroke;
neurovascular unit;
chemical drugs;
traditional Chinese medicine and compounds;
research progress
- From:
Chinese Pharmacological Bulletin
2016;32(3):310-313,314
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signals widely exist in live creatures,involved in many physical or pathological processes,including the cell prolif-eration, differentiation and apoptosis. Recent studies show that Wnt/β-catenin signaling pathway may play an important regula-tory role in the protective effects of neurovascular unit in ische-mic stroke. Some chemicals,such as sulindac and estradiol,and some compound traditional Chinese medicine which contains gly-coside( e. g. rhodiola rosea ) , volatile oil ( e. g. turmeric ) and compound prescription ( e. g. Dan Long Xing Nao Fang ) can protect the neurovascular unit by regulating the pathway. This aims to review the research progress of the protective effects of Wnt/β-catenin signaling pathway on the neurovascular unit in is-chemic stroke,with combination of chemicals and traditional Chi-nese medicine which can protect the neurovascular unit via Wnt/β-catenin signaling pathway. It aims to provide the methodology basis for elucidating the mechanism of drugs,and also provide a new idea for researching the new drug which can reduce the dis-ability rate caused by sequela of stroke.
