Influence of Xuefuzhuyu decoction on EPC repairing injured vascular endothelium

VernacularTitle:血府逐瘀汤调控内皮祖细胞修复损伤血管内皮的研究
Author: Wei ZHANG ; Xiaodan LIU ; Fei LI ; Lang CAO ; Changqing DENG
Publication Type:Journal Article
Keywords: Xuefuzhuyu decoction; EPC; blood vessel endothelium; eNOS; SDF-1/CXCR-4; PI3 K/p-Akt
From: Chinese Pharmacological Bulletin 2016;32(3):427-432,433
CountryChina
Language:Chinese
Abstract: Aim To investigate the role of Xuefuzhuyu decoction ( XFZYD ) combined with EPC in repairing damaged vascular endothelium using traditional Chi-nese medicine way of blood circulation combined with cell therapy. Methods The repaired situation of inju-ried endothelium was observed and the effect of XFZYD on EPC was analysed after the endothelial in-juried rats were gavaged XFZYD and vena caudalis in-jected EPC. Results Compared with EPC group and XFZYD group, the XFZYD joint EPC group ’ s endo-thelial thickness was reduced significantly(P<0. 05). And there appeared more significant role in lowering triglycerides, total cholesterol and increasing HDL lev-els( P<0. 05 ) , the calcium was decreased more sig-nificantly( P <0. 05 ); vascular eNOS protein expres-sion increased significantly(P<0. 05); vascular SDF-1 expression was significantly increased. Conclusion XFZYD can promote EPC repairing damaged endotheli-um, and the mechanism may be relevant to improving the environment and promoting the EPC homing.