Progress on roles and mechanisms of farnesoid X receptor (FXR) in chronic liver diseases
10.3969/j.issn.1001-1978.2016.03.004
- VernacularTitle:法尼酯衍生物X受体在慢性肝病中的作用及机制研究进展
- Author:
Wenxuan XU
;
Zili ZHANG
;
Shifeng ZHAO
;
Feng ZHANG
;
Li WU
;
Yin LU
;
Shizhong ZHENG
- Publication Type:Journal Article
- Keywords:
FXR;
viral hepatitis;
alcoholic fatty liver disease;
non-alcoholic fatty liver disease;
hepatic fibrosis;
hepatocellular carcinoma
- From:
Chinese Pharmacological Bulletin
2016;32(3):314-318,319
- CountryChina
- Language:Chinese
-
Abstract:
Farnesoid X receptor ( FXR) plays a key role in me-tabolism of substance, such as bile acid, lipid, glucose,( etc) . Newly published credible discoveries have claimed that as a reg-ulatory hub in metabolism, FXR is closely linked with diverse chronic liver diseases, including viral hepatitis, alcoholic fatty liver disease, nonalcoholic fatty liver disease, hepatic fibrosis and hepatocellular carcinoma. This review summarizes the roles and mechanisms of FXR during the courses of chronic liver dis-eases, aiming at providing novel insights and therapeutic target for antifibrotic research and drug development.
