The effects of renal denervation on hypothalamus angiotensinⅡand oxidative stress in myocardial infarction dogs
10.11958/20150032
- VernacularTitle:去肾交感神经术对心肌梗死犬下丘脑血管紧张素Ⅱ及氧化应激水平的影响
- Author:
Yijie MA
;
Chengzhi LU
;
Chao LI
;
Jin ZHANG
;
Li WANG
;
Lijun SONG
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
hypothalamus;
angiotensinⅡ;
oxidative stress;
disease models,animal;
renal dener-vation surgery
- From:
Tianjin Medical Journal
2016;44(3):327-329,330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of renal denervation (RDN) on hypothalamus angiotensinⅡ(AngⅡ) and oxidative stress in myocardial infarction (MI) dogs. Methods Eighteen mongrel dogs were randomly divided into MI group (n=6), RDN group (n=6) and sham operation group (n=6). Myocardial infarction model was made in the former two groups by gelatin sponge embolization of the left anterior descending artery. One week after MI, RDN was given to dogs in RDN group. Levels of AngⅡ, malondialdehyde (MDA), superoxide dismutase (SOD) and expression of gp91phox protein were detected four weeks after MI. Results Compared with control group, hypothalamus AngⅡ, MDA and expression of gp91phox protein were increased in MI group (P<0.01), but SOD was decreased (P<0.01). There was a negative correlation between AngⅡand SOD activity in MI group (r=-0.849, P < 0.01). There was a positive correlation between AngⅡ and expression of gp91phox protein in MI group (r=0.950, P<0.01). Compared with MI group, hypothalamus AngⅡ, MDA and expression of gp91phox protein were decreased in RDN group (P<0.01), but SOD was increased (P<0.01). Conclusion RDN can de?crease the level of hypothalamus AngⅡand the level of hypothalamus oxidative stress, and improve heart function of MI dogs.
