Observation of the effect of neoadjuvant chemotherapy of tegafur gimeracil oteracil potassium capsule combined with oxaliplatin in treatment of advanced gastri c cancer
10.3760/cma.j.issn.1008-6706.2016.03.022
- VernacularTitle:替吉奥胶囊联合奥沙利铂新辅助化疗治疗进展期胃癌的疗效观察
- Author:
Shoutian QIU
;
Jieyuan REN
;
Xuehu DAI
- Publication Type:Journal Article
- Keywords:
Tegafur gimeracil oteracil potassium capsule;
Oxaliplatin;
Advanced gastric cancer;
Curative effect;
Adverse reaction
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(3):400-403,404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and toxicity of S -1 combined with oxaliplatin neoadjuvant chemotherapy in treatment of advanced gastric cancer.Methods 70 patients with gastric cancer were divided into the study group and the control group by using the random number table method,35 cases in each group.The study group was given neoadjuvant chemotherapy with S -1 combined with oxaliplatin,and the control group was treated with FOLFOX regimen.After three cycles of treatment,the effect and the toxicity of the two groups were observed and com-pared.Results The total effective rate of the study group was 71.43%,which was significantly higher than 45.71%(16 /35)of the control group (χ2 =5.02,P <0.05).The CD8 and CD4 /CD8 in the study group before and after radiotherapy had statistically significant difference (P <0.05 ).WBC and neutrophils in the control group had significant difference before and after treatment (P <0.05),CD8,CD4 /CD8 in the study group were significantly higher than those in control group (P <0.05).The incidence of gastrointestinal adverse reactions in the control group was significantly higher than that in the study group (χ2 =3.75.4.02,all P <0.05).The 1 year survival rate in the study group was 85.71%,2 years survival rate was 57.14%,the recurrence rates of 1 year and 2 years were 20.00%,40.00%,which in the control group were 71.43%,42.86%,22.86%,42.86%,the differences were not statistically significant (χ2 =1.02,0.79,0.90,1.05,all P >0.05).Conclusion S -1 combined with oxaliplatin neoadjuvant chemotherapy has good effect in treatment of advanced gastric cancer,the side reaction is small,with high safety.
