Research Progress in Ameliorating EGFR-TKIs Acquired Resistance of Targeted Therapy in Lung Cancer by Traditional Chinese Medicine
10.3969/j.issn.1005-5304.2016.03.038
- VernacularTitle:中药改善肺癌靶向治疗表皮生长因子受体酪氨酸激酶抑制剂获得性耐药研究进展
- Author:
Hao LIU
- Publication Type:Journal Article
- Keywords:
EGFR-TKI;
acquired resistance;
traditional Chinese medicine;
targeted therapy;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(3):126-128,129
- CountryChina
- Language:Chinese
-
Abstract:
Acquired resistance of EGFR-TKIs has become the major limitation of the efficacy of targeted therapy for lung cancer. Lung cancer has been treated by traditional Chinese medicine (TCM) combined with EGFR-TKIs, which originated from clinic. In recent years, reversing research has been conducted based on clinic application to discuss TCM intervening, improving and reversing EGFR-TKIs acquired resistance becoming a novel target for research. This article reviewed mechanism and effects of TCM herbs and compounds’ with the efficacy of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis strengthening the body resistance, and invigorating the circulation of blood, and proposed that the whole regulation and targeted therapy of TCM may carry out synergistic effect and become innovation treatment model for lung cancer.
