Tuftsin can attenuates symptoms in experimental autoimmune encephalo-myelitis mouse
10.3969/j.issn.1000-484X.2016.03.006
- VernacularTitle:促吞噬肽（Tuftsin）在实验性自身免疫性脑脊髓炎小鼠中的神经功能改善作用
- Author:
Na JIA
;
Qiaoli WU
;
Yong JI
;
Xiaolin XU
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Experimental autoimmune encephalomyelitis;
Tuftsin
- From:
Chinese Journal of Immunology
2016;32(3):323-326,331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether Tuftsin can attenuates symptoms in experimental autoimmune encephalomyelitis mouses.Methods:C57BL/6 mice were immunized with MOG35-55 peptides,and evaluated for clinical neurological score every day .10 mice of the EAE were injected with Tuftsin subcutaneously .The spinal cord were stained by the methods of Haematoxylin Eosinstain , Luxol Fast Blue stain.The mRNA expression of IL-10 and TNF-αfrom brian tissue were detected at the 28 days by RT-PC method.Results:The controlled mice had no symptoms of disease and HE ,LFB were normal.Comparison EAE group with Tuftsin group of HE,LFB,EAE group were server than Tuftsin group.The expression of IL-10 in Tuftsin group was higher than EAE group.The expression of TNF-αin Tuftsin group was lower than EAE group .Conclusion: Tuftsin can attenuates symptoms in experimental autoimmune encephalomyelitis mouses .
