The effect of ulinastatin on NT-proB-NP and Picco in patients with severe sepsis
10.3760/cma.j.issn.1008-6706.2016.03.032
- VernacularTitle:乌司他丁对严重脓毒症患者脑钠肽与脉波轮廓温度稀释连续心排血量监测技术监测指标的影响
- Author:
Ziqiang MING
;
Linming YU
- Publication Type:Journal Article
- Keywords:
Sepsis;
Natriuretic peptide,brain;
Ulinastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(3):435-437,438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of ulinastatin on NT -proB -NP and Picco in patients with severe sepsis.Methods 50 patients with severe sepsis were randomly divided into the control group and observation group,25 patients in each group.The control group received the routine treatment,and the observation group received ulinastatin additionally.The venous blood was collected to determine cTn -I,NT -proBNP,TNF -αand Lac before treatment and 7 days after treatment.The APACHE Ⅱ and CFI were observed before treatment and 7 days after treat-ment.Results The differences of CFI,cTnI,NT -proBNP in the two groups before treatment were not significant (t =0.419,0.321,0.335,all P >0.05),after treatment,cTnI and NT -proBNP decreased more significantly(t =2.976,2.910,all P <0.05),while lifting more apparent CFI[(3.98 ±0.95)vs.(2.39 ±0.85),t =6.237,P <0.05]in the observation group than in the control group.The differences of TNF -αand Lac in the two groups before treatment were not significant (t =0.602,0.848,all P >0.05 ),after treatment,TNF -αand Lac decreased significantly faster in the observation group than in the control group(t =8.478,3.104,all P <0.05).After treat-ment,APACHE Ⅱ score decreased significantly in observation group than in the control group(t =2.321,P <0.05). Conclusion Ulinastatin had protective effects on heart function in patients with severe sepsis.
