Observation of the effect of enalapril folic acid in the treatment of H type hypertension
10.3760/cma.j.issn.1008-6706.2016.02.035
- VernacularTitle:依那普利叶酸片治疗H型高血压的疗效观察
- Author:
Guolin WU
;
Yingping SUN
- Publication Type:Journal Article
- Keywords:
Hypertension;
Hyperhomocysteinemia;
Enalapril;
Folic acid
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(2):282-284,285
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of enalapril folic acid in the treatment of H type hypertension. Methods 196 H type hypertension patients with carotid atherosclerosis were randomly divided into the enalapril folic acid tablets group(leaf group 99 cases)and the control group(enalapril group 97 cases),respectively,enalapril folic acid tablets and enalapril,once a day.Continuous administration of 10 months,before and after treatment,the blood pressure control level,plasma homocysteine levels and carotid intima media thickness were compared between the two groups.Results ,Before and after treatment,the systolic blood pressure in the leaf group were (159.51 ±8.55)mmHg, (138.68 ±7.82)mmHg,and the diastolic blood pressure were (98.11 ±7.44)mmHg,(82.98 ±5.22)mmHg.In the enalapril group,before and after treatment,the systolic blood pressure were (160.10 ±9.12)mmHg,(139.47 ± 7.99)mmHg,and the diastolic blood pressure were (97.88 ±7.62)mmHg,(83.12 ±5.57)mmHg.Blood pressure before and after treatment in the two groups were significantly different(all P <0.05),there were no significant differ-ence between the two groups(all P >0.05).In the leaf group,before and after treatment,the plasma homocysteine concentrations were (16.89 ±5.62)μmol/L,(10.37 ±3.06)μmol/L,there was significant difference(P <0.05), and in the enalapril group before and after treatment,the plasma homocysteine concentrations were (17.11 ± 6.33)μmol/L,(16.88 ±6.48)μmol/L,there was no significant difference(P >0.05).In the leaf group,before and after treatment the carotid artery intima media thickness were (1.28 ±0.33)mm,(1.08 ±0.36)mm,there was sig-nificant difference(P <0.05),and in the enalapril group before and after treatment the carotid artery intima media thickness were (1.29 ±0.38)mm,(1.31 ±0.43)mm,there was no significant difference(P >0.05).Conclusion Enalapril folic acid tablets in treatment of H type hypertension has significant efficacy,it can reduce blood pressure and plasma homocysteine levels and delay the progression of atherosclerosis.
