Determination of Bacterial Endotoxin in Iodixanol by Kinetic Turbidimetric Method
- VernacularTitle:动态浊度法定量测定碘克沙醇中细菌内毒素的含量
- Author:
Jiali ZHU
;
Peng DUAN
;
Hui CAO
;
Jiaxiu HUANG
;
Lin WANG
;
Chunjuan XIE
;
Biao FAN
- Publication Type:Journal Article
- Keywords:
Iodixanol;
Kinetic turbidimetric method;
Bacterial endotoxin
- From:
China Pharmacist
2016;19(2):384-386,387
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method to determine the content of bacterial endotoxin in iodixanol. Methods:The standard curve of kinetic turbidimetric method was established and the dilution ratio was optimized by interference test. Bacterial endotoxin in the samples was determined. Results:The dilution ratio of 1 ∶12 did not interfere with the test. The recovery rate of bacterial endotox-in was 50%-200%. Conclusion:The kinetic turbidimetric method is suitable for the determination of bacterial endotoxin in iodixanol.
