The characteristics of liver tissue pathology and immunohistochemistry in HBeAg negative hepatitis B virus infection
10.3760/cma.j.issn.1008-6706.2016.02.011
- VernacularTitle:乙型肝炎e抗原阴性的慢性乙型肝炎病毒感染患者肝组织病理和免疫组化特点研究
- Author:
Sumei CHEN
;
Yong DENG
;
Chengzu LIN
;
Shaopeng KE
;
Qi LIN
;
Zhijun SU
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Pathology,clinical;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(2):204-207,208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of liver tissue pathology and immunohistochemistry in HBeAg negative hepatitis B virus infection and provide a reference for the diagnosis and treatment.Methods Liv-er biopsy was carried out on the 63 HBeAg negative HBV infections,then liver tissue inflammation,fibrosis and immu-nohistochemistry were detected.Results In HBeAg negative and HBV DNA negative patients,both the male and female,ALT normal and mildly abnormal group had no significant difference in liver inflammation and fibrosis(all P >0.05).Among the patients with fibrosis stage ≥S2,the ratio(30 /41,73.2%)of patients above 30 years old was higher than that below 30 years old (6 /14,46.2%)(P =0.041).There were no differences in liver tissue inflamma-tion(5 /34,14.7% vs.9 /29,31.0%)and fibrosis (8 /34,23.5% vs.8 /29,27.6%)between HBV DNA negative group and HBV DNA positive patients(all P >0.05).Only 2 cases of HBcAg positive in those 63 cases of liver tissue immunohistochemistry.Conclusion The liver tissues of HBeAg negative HBV DNA negative or positive patients have obvious liver inflammation and fibrosis,and the necessary treatment measures should be taken.HBcAg positive is extremely low in those liver tissue immunohistochemistry,which lead to the pathogenesis of liver inflammation needs further research.
