Progress of T helper cell 17,regulatory T cell,podocyte injury and primary glomerular disease
10.3760/cma.j.issn.1673-4408.2016.01.018
- VernacularTitle:Th17、Treg及足细胞损伤与原发性肾小球疾病研究进展
- Author:
Lirong HE
;
Xiaoshan SHAO
- Publication Type:Journal Article
- Keywords:
T helper cell 17;
Regulatory T cell;
Podocyte injury;
Primary glomerular disease
- From:
International Journal of Pediatrics
2016;43(1):66-69,70
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,T helper cell 17(Th17),regulatory T cell(Treg) and podocyte injury attrac-ted widespread attention in the pathogenesis of primary glomerular disease. Th17 cells have the function of re-cruiting neutrophils and macrophages to the infected tissue through the secretion of cytokines such as IL-17. Treg cells have immune function, mediated immune tolerance, protecting the body against inflammatory injury. The imbalance of Th17 cells increase and Treg cells decrease could play an important role in the pathogenesis and progression of primary glomerular disease. As the important part of the glomerular filtration barrier,podocyte be-comes the focus in recent years. Study on relationship among Th17,Treg,podocyte injury and primary glomeru-lar disease will provide more theoretical basis for the prevention and treatment of primary glomerular disease.
