Study on Varieties and Contents of Related Substances in Cefonicid Sodium by HPLC and MS
- VernacularTitle:HPLC和MS法研究头孢噻吩钠有关物质的种类与含量
- Author:
Jinghui GAO
;
Jingjie SHI
;
Rui WANG
;
Suxue YUE
- Publication Type:Journal Article
- Keywords:
Cefalothin sodium;
Related substances;
HPLC;
MS
- From:
China Pharmacist
2016;19(2):274-276,286
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the varieties and contents of related substances in cefalotin sodium by HPLC and MS. Methods:The quantitative determination of impurity spectra was carried out using self-contrast method, and UPLC-MS was used to preliminarily i-dentify the variety of impurities. Results:Through the study on the ascription and content of the related substances, there were 6 sub-stances existing in cefalotin sodium, and through the structure analysis, the 6 substances showed antibiotic action and toxicity. Conclu-sion:The method is simple, stable and repeatable, which can be used for the determination of cefalothin sodium and related sub-stances.
