Observation on Therapeutic Efficacy of Alternate Use of Azithromycin and Acetylspiramycin in the Treat-ment of Mycoplasma Pneumonia in Children
- VernacularTitle:阿奇霉素与乙酰螺旋霉素交替使用治疗小儿支原体肺炎疗效观察
- Author:
Ligao WANG
- Publication Type:Journal Article
- Keywords:
Mycoplasma pneumonia;
Azithromycin;
Acetylspiramycin;
Efficacy
- From:
China Pharmacist
2016;19(2):296-297,298
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the therapeutic efficacy of alternate use of azithromycin and acetylspiramycin with sequential therapy and azithromycin alone in the treatment of mycoplasma pneumonia in children. Methods:In the outpatient department, 84 ca-ses of mycoplasma pneumonia children were randomly divided into group A (43 cases) and group B (41 cases). The group A was giv-en azithromycin (10mg·kg-1 ·d-1 ,ivd,qd) with intravenous infusion for 7 days, and then after 4-day withdrawal, orally given az-ithromycin 10 mg·kg-1 ·d-1 qd for 3 days followed by 4-day withdrawal,and till 3 weeks ( sequential therapy) . The group B was giv-en azithromycin (10mg·kg-1 ·d-1 ,ivd,qd) with intravenous infusion for 7 days followed by oral administration with acetylspiramycin 25-30 mg·kg-1 ·d-1 tid for 2 weeks. Results:The clinical efficacy and adverse reactions of the two groups were compared. The total effective rate of group A and group B was 86. 0% and 100%, respectively, and the effective rate of group B was obviously higher than that of group A (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0. 05). Conclusion:The alternate use of azithromycin and acetylspiramycin in the treatment of mycoplasma pneumonia in children is better than the sequential therapy of azithromycin alone.
