Establishment of Determination Method for Benzoic in Ibuprofen Suspension
- VernacularTitle:布洛芬混悬液中苯甲酸测定方法的建立
- Author:
Wujun YANG
;
Xuefeng LIU
- Publication Type:Journal Article
- Keywords:
Ibuprofen suspension;
Benzoic;
HPLC
- From:
China Pharmacist
2016;19(2):382-383,384
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method to determine benzoic in ibuprofen suspension. Methods:The determination of ben-zoic was performed on a Kromasil C18 (250 mm × 4. 6 mm, 5 μm) column with the mobile phase consisting of 0. 05 mol·L-1 monopo-tassium phosphate and acetonitrile (72 ∶28). The detection wavelength was 235 nm and the column temperature was 30℃. The injec-tion volume was 10μl. Results:The limit of detection was 3. 57 ng and benzoic had a good linear relationship within the range of 12. 5-200. 0 μg·ml-1(r=0. 999 9). The solution was stable in 24 hours. The average recovery was 98. 42% and RSD was 0. 98% (n=9) . Conclusion:The method is simple, repeatable and accurate, and can be used for the determination of benzoic in ibuprofen sus-pension.
