Effects of ANO1 on tumorigenesis
10.3969/j.issn.1000-4718.2016.04.029
- VernacularTitle:钙离子激活的氯离子通道蛋白ANO1在肿瘤发病机制中的作用
- Author:
Lili MEI
;
Zhizhou SHI
- Publication Type:Journal Article
- Keywords:
Anoctamin 1;
tumors;
Proliferation;
Metastasis
- From:
Chinese Journal of Pathophysiology
2016;32(4):759-761,768
- CountryChina
- Language:Chinese
-
Abstract:
Anoctamin 1 (ANO1) is a calcium-activated chloride channel and is amplified and over-expressed in gastrointestinal stromal tumor, breast cancer, bladder cancer, head and neck squamous cell cancer, esophageal squa-mous cell cancer, prostate cancer and pancreatic cancer.The amplification and over-expression of ANO1 are associated with lymph node metastasis and poor prognosis.ANO1 promotes tumor formation and metastasis, and the drugs that inhibit the activity or expression of ANO1 show antitumor effects.Therefore, ANO1 may promote the tumorigenesis, and may be a molecular biomarker and a new target for cancer therapy.
