Comparison of LOXL-2 Expression between Active Systematic Scleroderma and Active Mixed Connective Tissue Disease

VernacularTitle:系统性硬化症和混合性结缔组织病活动期血清中LOXL-2的比较
Author: Yao CHENG ; Xiaofei WANG ; Xiaoli ZHANG ; Na ZHANG ; Xingang ZHANG
Publication Type:Journal Article
Keywords: systematic scleroderma; mixed connective tissue disease; lysyl oxidase like protein-2; fibroblast
From: Journal of China Medical University 2016;45(5):414-416,421
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of lysyl oxidase like protein?2(LOXL?2)in the sera of patients with active systemic scleroder?ma(SSc)and mixed connective tissue disease(MCTD). Methods An enzyme?linked immunosorbent assay was adopted to measure LOXL?2 in the serum of 20 patients with active SSc,20 patients with active MCTD,and 20 healthy controls. The measurements among different groups was com?pared,and correlations between LOXL?2 levels and clinical manifestations of SSc and MCTD were examined. Results The levels of LOXL?2 ex?pression in MCTD and SSc groups were significantly higher than those in control group(P<0.05 for all groups). LOXL?2 expression is also related to the presence of skin lesions in SSc(r=0.982 P=0.001). Conclusion High serum level of LOXL?2 in these patients with active SSc and active MCTD suggests that LOXL?2 may be involved in the process of fibrosis and the resulting vasculitis in multiple organs.