Analysis of the correlation between the expression level of TNF-α,IL-10 and CD4+ cells in patients with HIV infection
10.3969/j.issn.1673-4130.2016.08.027
- VernacularTitle:HIV感染者CD4＋T细胞数与IL-10、TNF-α表达水平的相关性
- Author:
Xiujuan PENG
;
Guoxiong LIU
;
Zili YANG
;
Shan LIU
;
Haoyue REN
;
Shuguang JIA
- Publication Type:Journal Article
- Keywords:
human immunodeficiency virus;
acquired immunodeficiency syndrome;
interleukin-10;
tumor necrosis factor-α
- From:
International Journal of Laboratory Medicine
2016;37(8):1081-1082,1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between interleukin 10(IL‐10) ,tumor necrosis factor (TNF‐α) and serum CD4+ T‐lymphocytes cell in people who infected HIV .Methods The HIV antibody screening test ,IL‐10 and TNF‐αmeasurement adopted enzyme‐linked immune‐sorbent assay(ELISA) .The HIV antibody confirm test adopted western blot(WB) and CD4+ cell count determination used flow cytometry .Results Compared with the normal control group(NC group) ,the concentration of TNF‐αand IL‐10 in patients group have statistically significant difference(P<0 .05) .Moreover ,the extent of the increase in group A(pa‐tients with the CD4+ T cell count less than 3 .5 × 105 cells/mL) was higher than that in group B(patients with the CD4+ T cell count no less than 3 .5 × 105 cells/mL) .Conclusion Due to the defect of the immune system ,the serum concentration of TNF‐αand IL‐10 in people infected with HIV would increased ,and the increase of the concentration could be more significant in patients whose CD4+cell count obviously decrease .This study have shown that dynamic measurement of TNF‐α and IL‐10 concentration would provide data to konw the patients′immune status and illness development .
