Effect of astragalus injection combined with beta-adrenoceptor antagonist on BNP,IL-1β,IL-6 and TNF-αlevels in senile heart failure patients
10.3969/j.issn.1005-1678.2016.04.47
- VernacularTitle:黄芪注射液联合β受体阻滞剂对老年心力衰竭患者BNP、IL－1β、IL－6及TNF－α的影响
- Author:
Shengqiang SHEN
;
Mengqiu ZHAO
;
Kaikun ZHANG
- Publication Type:Journal Article
- Keywords:
astragalus injection;
beta-adrenoceptor antagonist;
senile heart failure
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):150-151,154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of astragalus injection combined with beta-adrenoceptor antagonist on serum levels of brain natriuretic peptide ( BNP) , interleukin1β( IL-1β) , IL-6 and tumor necrosis factorα( TNF-α) in the treatment of elderly patients with heart failure. Methods 78 elderly patients with heart failure from April 2013 to April 2015 in department of cardiology of the second hospital of Yuhang district were selected and divided into control group and experimental group with 39 cases in each group.All patients received correction of the electrolyte and acid-base balance and other conventional treatment.The control group received carvedilol by oral, the experimental group received astragalus injection on the basis of control group, with a course of 30 days.The serum BNP,IL-1β,IL-6 and TNF-αlevels pre-and post-treatment in two groups were compared. Results Compared with pre-treatment, the serum IL-1β,IL-6,TNF-α,and BNP levels post-treatment in two groups were lower(P<0.05).Compared with the control group post-treatment, the IL-1β,IL-6,TNF-αand BNP levels in experimental group were lower(P <0.05).Conclusion Astragalus injection combined with beta-adrenoceptor antagonist could significantly improve the clinical sign of elderly patients with heart failure, the mechanism may be reducing the serum levels of IL-1β,IL-6,TNF-αand BNP.
