Advance in mechanism and application of antibacterial peptide
10.3969/j.issn.1005-1678.2016.04.05
- VernacularTitle:抗菌肽作用机制及应用研究进展
- Author:
Shicai LIU
;
Linlin FAN
;
Heng ZHENG
;
Qiuyi ZHANG
- Publication Type:Journal Article
- Keywords:
antibiotic resistance;
antimicrobial peptides;
action mechanism;
design of antimicrobial peptides;
application progress
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(4):20-23,28
- CountryChina
- Language:Chinese
-
Abstract:
In the era of outbreaking of antibiotic resistance, the discovery of new antibacterial drugs is emergent.Antimicrobial peptides are important components of the natural defenses of most living organisms against invading pathogens.The unique antibacterial mechanism, direct bactericidal effect, relatively slow of resistance acquirement, and can used alone or combined with antibiotics, make antimicrobial peptides be attractive potential antibacterial drugs.In this paper, we review the physicochemical property of antibacterial peptides, action mechanism and design of antimicrobial peptides, and give a brief introduction of several promising antimicrobial peptides.
