Correlation between ADC value and Ki-67 expression in rectal cancer
10.3969/j.issn.1002-1671.2016.04.015
- VernacularTitle:直肠癌磁共振扩散加权成像 ADC 值与 Ki-67表达水平的相关性
- Author:
Zheng WANG
;
Danke SU
;
Shaolü LAI
;
Guanqiao JIN
;
Maolin XU
;
Wei KANG
;
Yang ZHAO
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
diffusion-weighted imaging;
apparent diffusion coefficient;
Ki-67
- From:
Journal of Practical Radiology
2016;32(4):551-553,557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between apparent diffusion coefficient (ADC)value of MR diffusion weighted imaging (DWI)and Ki-67 expression in rectal cancer.Methods The data of 47 patients with rectal cancer confirmed by pathology were retrospectively analyzed.Pelvic MRI,rectum DWI and enhanced examination were performed preoperatively.According to the Ki-67 index,the patients were divided into A-D four Groups:Group A with Ki-67 <10% (-),Group B with Ki-67 10%-25%(+),Group C with Ki-67 26%-50%(++);and Group D Ki-67 > 50%(+++).ADC values were calculated in each group to analyze the correlation with the Ki-67 expression levels.Results The mean ADC value were (1.280 ± 0.200 )× 10 -3 mm2/s in Group A (13 cases),(1.044±0.046)×10 -3 mm2/s in Group B (14 cases),(0.987 ±0.256)×10 -3 mm2/s in Group C (9 cases), and (0.85 1±0.099)×10 -3 mm2/s in Group D (1 1 cases).The mean ADC values were significantly different in the different groups with different levels of Ki-67 expression (P =0.001).ADC value and Ki-67 expression were moderate negatively correlated (r = -0.577, P=0.000).Conclusion DWI and ADC measurement can evaluate indirectly the cell proliferation and prognosis of rectal tumor to some extent.
