Clinical effect of caffeine citrate combined with CPAP in the treatment of primary apnea of prematurity
10.3760/cma.j.issn.1008-6706.2016.08.004
- VernacularTitle:枸橼酸咖啡因联合持续正压通气治疗早产儿原发性呼吸暂停的疗效研究
- Author:
Xiaomei ZHOU
;
Li NAN
;
Yingrong LIN
- Publication Type:Journal Article
- Keywords:
Caffeine citrate;
Continuous positive airway pressure;
Primary apnea,prematurity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(8):1133-1135,1136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of caffeine citrate combined with continuous positive airway pressure( CPAP) in the treatment of primary apnea of prematurity.Methods 80 premature infants with primary apnea who received therapy from January 2014 to August 2015 were selected as research subjects.According to ran-dom number table,the infants were divided into two groups equally.Besides conventional treatments,the control group received treatment of caffeine citrate,while the observation group received CPAP and caffeine citrate.Then,the cura-tive efficacy,situation of apnea and adverse reactions were compared.Results The total effective rate between the observation group and the control group had statically significant difference(95.0%vs.77.5%,P<0.05) .Compared with the control group,the observation group had statistically less seizure frequency,shorter duration of seizure and disappearance time of symptoms(all P<0.05).During the treatment,incidence rates of tachycardia,dysphoria and electrolyte disturbance in the observation group were statistically lower than those in the control group (all P<0.05), while the incidence of feeding intolerance in the two groups had no statistically significant difference ( P >0 .0 5 ) . Conclusion Caffeine citrate in combination with CPAP is effective for primary apnea of prematurity,which can sig-nificantly increase curative efficacy,lessen seizure frequency of apnea,shorten duration of seizure and disappearance time of symptoms with less adverse reactions.
