Immunophenotype and bone marrow of chronic lymphocytic leukemia
10.3969/j.issn.1673-4130.2016.07.012
- VernacularTitle:69例慢性淋巴细胞白血病的免疫表型及骨髓象分析
- Author:
Wei QU
- Publication Type:Journal Article
- Keywords:
chronic lymphocytic leukemia;
phenotype;
bone marrow
- From:
International Journal of Laboratory Medicine
2016;37(7):898-899,903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of immunophenotype and bone marrow in chronic lymphocytic leukemia (CLL) in order to provide certain reference for its clinical diagnosis and treatment .Methods A total of 69 cases of CLL in our hos‐pital from January 2013 to January 2015 were selected .The immune 69 cases was analyzed by using the single parameter and multi‐parameter flow cytometry .The bone marrow and blood examinations were performed and the myeloproliferative degree was ana‐lyzed .Results Among 69 cases of CLL ,33 cases (47 .83% ) were LL/SL‐MC ,16 cases (23 .19% ) were CLL/PLL‐MC ,9 cases (13 .04% ) were TSL ,4 cases (5 .80% ) were ATLL ,4 cases (5 .80% ) were PLL and 3 cases (4 .34% ) were HCL .The majority of CLL cases were more than 50 years old .The myeloproliferative degree was hyperactive in 12 cases (17 .39% ) ,significantly active in 10 cases (14 .49% ) and active in 47 cases (68 .12% );the myeloid‐erythroid ratio was increased in 17 cases (24 .64% ) ,normal in 29 cases (42 .03% ) and reduced in 23 cases (33 .33% );the megakaryocyte count was increased in 3 cases (4 .35% ) ,normal in 30 cases (43 .48% ) and reduced in 36 cases (52 .17% ) .All 69 cases expressed CD19 and CD20 with the positive rate of 100% ;sec‐ondly expressed CD22 with the positive rate of 98 .55% ;the CD23 positive rate was 97 .10% ,the CD5 positive rate was 86 .96% ;all cases did not express CD10 .Conclusion The immunophenotype in 69 cases of CLL was mainly the mixed type with higher my‐eloproliferative degree ;the immunophenotype expressed CD19 and CD20 in all cases ,secondly expressed CD22 and CD23 ,and did not express CD10 .
