Value of detections of antinuclear antibody combined with anti-cardiolipin antibody, anti-sperm antibody and anti-β2-glycoprotein I antibody in female infertility
10.3969/j.issn.1673-4130.2016.07.018
- VernacularTitle:抗核抗体联合抗心磷脂抗体、抗精子抗体和抗β2糖蛋白I抗体检测在女性不孕不育中的价值
- Author:
Qidang HUANG
;
Zeyong LI
;
Xiaoyun WU
;
Fang YAN
- Publication Type:Journal Article
- Keywords:
infertility;
antinuclear antibody;
anti-cardiolipin antibodies;
antisperm antibody;
anti-β2-glycoprotein I anti-body
- From:
International Journal of Laboratory Medicine
2016;37(7):915-916,919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of detections of anti‐nuclear antibody (ANA) combined with anti‐cardiolipin anti‐body (ACA) ,anti‐sperm antibody (AsAb) and anti‐beta 2 glycoprotein I (β2 GPI) antibody in the diagnosis of female infertility dis‐ease .Methods A total of 187 female cases of infertility (infertility group) were detected serum ANA and AsAb by the indirect im‐munofluorescence assay ,and ACA andβ2 GPI antibody by the enzyme linked immunosorbent assay (ELISA) .ANA ,ACA ,AsAb andβ2 GPI antibody also were detected in 80 females cases of normal fertility (normal group) .Results Among 187 cases of female infer‐tility ,ANA positive rate was 18 .1% (34/187) and which in the normal group was 2 .5% (2/80) .The ACA positive rate was 22 .3%(43/187) in the infertility group and 5 .0% (4/80) in the normal group ;the AsAb positive rate was 18 .7% (35/187) in the infertil‐ity group and 3 .8% (3/80) in the normal group ;theβ2 GPI positive rate was 20 .3% (38/187) in the infertility group and 3 .8% (3/80) in the normal group;the differences between the two groups had statistical significance (P<0 .05) .Conclusion Infertility is closely correlated with the in vivo existence of ANA ,ACA ,AsAb andβ2 GPI antibody ,the joint detection is conducive to find the e‐tiology of infertility and improve the clinical diagnosis rate .
