The relationship between HPV infection and cervical cancer and precancerous lesion
10.3760/cma.j.issn.1008-6706.2016.08.018
- VernacularTitle:人乳头瘤病毒感染与宫颈癌及癌前病变的关系
- Author:
Hui JIA
;
Jianjia YANG
;
Min CUI
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Precancerous conditions;
Human papillomavirus 6
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(8):1185-1187,1188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between HPV infection and the incidence of cervical canc-er and precancerous lesions in women.Methods 108 patients with cervical disease who accepted cervical screening were chosen as the research subjects, and they were given colposcopy and pathological examination, hybrid capture 2 generation method for quantitative detection of HPV-DNA content,RLU/CO was used for viral load and HPV-DNA content was more than 1ng/L(RLU/CO>1) can be judged as positive.Results The positive rates of HPV-DNA was 35.00%,67.74%and 95.83%of chronic cervicitis,cervical cancer precursor lesions( CIN) and invasive cervical squamous cell carcinoma,the difference was statistically significant(χ2 =10.73,P<0.05) .The positive rates of HPV DNA in patients with typeⅠCIN,typeⅡCIN,typeⅢCIN were 44.44%,62.50%and 95.00%respective-ly,the difference was statistically significant(χ2 =11.43,P<0.05).HPV-DNA and the positive rate of cervical cancer patients with histological grade,clinical stage,lymph node metastasis,there was no significant correlation(χ2 =1.76,1.44,1.89, all P >0.05 ) .Conclusion HPV -DNA positive rate increased with the severity of cervical lesions in patients,but it had no significant correlation with clinical and pathological parameters,the active prevention of HPV infection of cervical cancer prevention had important significance.
