Mechanisms and significance of tumor dormancy
10.3760/cma.j.issn.1009-9921.2016.03.001
- VernacularTitle:肿瘤休眠的机制及其意义
- Author:
Kefu WU
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
- Publication Type:Journal Article
- Keywords:
Hematopoietic malignancies;
Tumor dormancy;
Mechanism;
Precise medicine
- From:
Journal of Leukemia & Lymphoma
2016;25(3):129-133,138
- CountryChina
- Language:Chinese
-
Abstract:
Dormant follicular lymphoma, prostate carcinoma and breast carcinoma are frequently detected by autopsy of non-tumor patients. Dormancy of malignant cells in hematopoietic malignancies is associated with genesis, development and treatment of these diseases. Dormancy is the universally applied strategy by living organism during survival competition. As the in vivo neoplasm, tumor cells keep this property. Recently, much attention has been paid to the mechanisms of tumor dormancy. These studies not only have theoretical significance, provide new ways for the prevention and treatment of tumors, but also help the understanding of over-diagnosis, over-treatment and provide clues for precise medicine. This paper reviewed cellular mechanism of tumor cell dormancy,immunological and vascular regulation of dormant tumors. The clinical significance,application of these mechanisms and direction of further study, which will provide new clues for the treatment of hematopoietic malignancies, were also discussed.
