Efficacy improvement of chimeric antigen receptor T-cell immunotherapy: reports from the 57th American Society of Hematology annual meeting
10.3760/cma.j.issn.1009-9921.2016.01.001
- VernacularTitle:提高嵌合抗原受体T细胞疗效的研究进展:第57届美国血液学会年会报道
- Author:
Yangqiu LI
;
Chengwu ZENG
- Publication Type:Journal Article
- Keywords:
Chimeric antigen receptor T-cells;
Hematological malignancy;
Cytotoxicity;
Signaling pathway inhibitors;
American Society of Hematology annual meeting
- From:
Journal of Leukemia & Lymphoma
2016;25(1):1-3,11
- CountryChina
- Language:Chinese
-
Abstract:
How to improve the efficacy of chimeric antigen receptor T-cell (CAR-T) is one of the key points for manufacture and application of CAR-T. In this review, the studies from the 57th American Society of Hematology (ASH) annual meeting regarding to the strategies for optimal CAR-T activity were summarized, including pathway inhibitors, enhancement antigen expression of target cells, optimization of conditioning chemotherapy, as well as the novel technology for CAR-T generation.
