Chloride channels and kidney diseases
10.3969/j.issn.1000-3606.2016.02.017
- VernacularTitle:氯离子通道与肾脏病
- Author:
Jinyun PU
;
Jianhua ZHOU
- Publication Type:Journal Article
- Keywords:
chloride channels;
Bartter syndrome;
Dent’s disease
- From:
Journal of Clinical Pediatrics
2016;(2):150-153,157
- CountryChina
- Language:Chinese
-
Abstract:
Chloride ion is an important anion in organisms, managing various physiological events. A particular gene mu-tation leads to involved channel deifciency and to develop channelopathy. In kidney, different chloride channels distribute along certain fractions of the renal tubule, located at apical and basolateral membranes of tubular epithelial cells. Previous studies dis-covered that voltage-sensitive chloride channels in kidney are associated with Bartter syndrome and Dent’s disease. In addition, the kidney can be involved by cystic ifbrosis resulting from dysfunction of cystic ifbrosis transmembrane conductance regulator. In this review, the function and mechanism of chloride channels in maintenance of normal renal function, and the renal diseases caused by related gene defects were discussed.
