Pattern of Recurrence after Curative Resection of Local (Stage I and II) Non-Small Cell Lung Cancer: Difference According to the Histologic Type.
10.3346/jkms.2004.19.5.674
- Author:
Yong Soo CHOI
1
;
Young Mog SHIM
;
Kwhanmien KIM
;
Jhingook KIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jkim@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Carcinoma, Non-Small-Cell Lung;
Pneumonectomy;
Neoplasm Recurrence, Local
- MeSH:
Brain Neoplasms/mortality/secondary;
Carcinoma, Non-Small-Cell Lung/*mortality/*pathology/surgery;
Carcinoma, Squamous Cell/mortality/pathology/surgery;
Disease-Free Survival;
Female;
Follow-Up Studies;
Humans;
Lung Neoplasms/*mortality/*pathology/surgery;
Male;
Middle Aged;
Neoplasm Recurrence, Local/mortality/pathology;
Neoplasm Staging/*mortality;
Pneumonectomy;
Risk Factors;
Survival Analysis
- From:Journal of Korean Medical Science
2004;19(5):674-676
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of the present study was to evaluate the pattern of recurrence after complete resection of pathological stage I, II non-small cell lung cancer, especially according to the cell type. We reviewed the clinical records of 525 patients operated on for pathologic stage I and II lung cancer. The histologic type was found to be squamous in 253 and non-squamous in 229 patients. Median follow-up period was 40 months. Recurrences were identified in 173 (36%) of 482 enrolled patients; distant metastasis in 70%, distant and local recurrence in 11%, and local recurrence in 19%. Distant metastasis was more common in non-squamous than in squamous cell carcinoma (p=0.044). Brain metastasis was more frequently identified in non-squamous mthan in squamous cell carcinoma (24.2% vs. 7.3%. p=0.005). Multivariate analyses showed that cell type is the significant risk factor for recurrence-free survival in stage I and stage II non-small cell lung cancer. Recurrence-free survival curves showed that non-squamous cell carcinoma had similar risks during early periods of follow-up and more risks after 2 yr from the operation compared to squamous cell carcinoma. Pathological stage and histologic type significantly influence recurrence-free survival.
