Study on effect of UC-MSC in IPF experimental model induced by bleomycin in mice
- VernacularTitle:脐带间充质干细胞对博来霉素诱导实验性小鼠肺纤维化模型影响的研究
- Author:
Lijun FENG
;
Yingchao ZHANG
- Publication Type:Journal Article
- Keywords:
umbilical cord-derivedumbilical cord-derived cell;
bleomycin;
idiopathic pulmonary fibrosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):19-21,25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate protective of umbilical cord-mesenchymal stem cells ( UC-MSC ) on idiopathic pulmonary fibrosis ( IPF ) experimental mode was induced by bleomycin in mice .Methods IPF experimental mode induced by bleomycin with intratracheal injection , and then the fourth generation UC-MSC was injected in caudal vein.The lung tissues were obtained to evaluate the influence of UC-MSC on IPF by the observation of histological evaluation(HE) and Masson staining, the detection content of hydroxyprine(HYP), superoxyde dismutase(SOD) and malonaldehyde ( MDA) .Results The HE and Masson staining showed that bleomycin +UC-MSC group could alleviate inflammatory cell infiltration and pulmonary interstitial collagen deposition.bleomycin+UC-MSC group could decline the content of HYP(P<0.01), MDA(P<0.05) and improve the content of SOD(P<0.01)compared with bleomycin group.Conclusion UC-MSC exhibits an protective effect on IPF experimental mode induced by bleomycin in mice.
