Methotrexate combined with mifepristone in treatment of 130 cases heterotopic pregnancy
- VernacularTitle:甲氨蝶呤联合米非司酮治疗异位妊娠130例
- Author:
Xiaolin LV
;
Yan ZHU
;
Hao AI
;
Fangxu CHEN
- Publication Type:Journal Article
- Keywords:
mthotrexate;
mifepristone;
heterotopic pregnancy;
efficacy
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):76-77,80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the efficacy of methotrexate combined with mifepristone in treatment of 130 cases heterotopic pregnancy. Methods 130 cases heterotopic pregnancy from January 2014 to December 2014 in obstetrics and gynecology department of First Affiliated Hospital of Liaoning Medical University were divided into observation group and control group, randomly, 65 cases in each group.Patients in control group were treated with 1 mg/kg methotrexate of intramuscular injection, one time per day; patients in observation group were treated with mifepristone of oral, one time per day, 75mg per time on the basis of control group.The serum β-subunit of human chorionic gonadotropin (β-hCG), normal pregnancy rate, size of enclosed mass, rate of treatment success and adverse reactions in two groups were compared.Results The recovery time of serum β-HCG in observation group was shorter than that in control group ( P <0.05 ) , and normal pregnancy rate in observation group was higher than that in control group (P<0.05).After 7 and 14 days’ treatment, size of enclosed mass in observation group was smaller than that in control group (P<0.05).After two months’ treatment, the efficacy in observation group was higher than that in control group (92.31%vs.61.54%;χ2 =17.33,P<0.05).There was no significant difference in adverse reactions rate between two groups (χ2 =0.34,P>0.05).Conclusion Methotrexate combined with mifepristone could improve the clinical efficacy which is a safe therapy with few adverse reactions.
