Expressions of microRNA-101 and cyclooxygenase-2 in colorectal cancer
10.3969/j.issn.1006-5725.2016.05.016
- VernacularTitle:microRNA-101和COX-2在结肠癌中的表达及其临床意义
- Author:
Mingguang LAI
;
Haitao QING
;
Lisheng WANG
- Publication Type:Journal Article
- Keywords:
Colorectal Cancer;
miRNA-101;
Cyclooxygenase 2
- From:
The Journal of Practical Medicine
2016;32(5):739-741,742
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expressions of miR-101 and COX-2 in colorectal cancer. Methods Thirty-twocolorectal cancer specimens and paired paracancer tissues were collected for assessment of miR-101 and COX-2 expressions by real-time quantitative PCR. Thecorrelation between miR-101 and COX-2 , as well as their correlations with the pathologywere analyzed. Results The expression level of miR-101 and COX-2 mRNA in the cancer tissues was significant difference between the cancer and para-cancer tissues (P < 0. 01). Also, miR-101 expression was negatively correlated with COX-2 mRNA expression (r = -0.373 5, P < 0.01). Furthermore,miR-101 expression was significantlydecreased along with the deterioration of tumor differentiation grade(P < 0.05). Compared with which in Dukes A ~ B stage, COX-2 expression was overexpressed and miR-101 was down-regulatedin colorectal cancer tissue inDukes C ~ Dstage , butnosignificant difference was found (P > 0.05). Conclusion Down-regulated miR-101 expression andparallel COX-2 overexpression hasbeen linked to colorectal cancer. miR-101 and COX-2might be thepotentialdiagnostic markers and therapeutic targets.
