Association between ADAM33 gene polymorphism with chronic obstructive pulmonary disease incidence in Kazakh of Xinjiang
10.11958/j.issn.0253-9896.2015.12.002
- VernacularTitle:新疆地区哈萨克族慢性阻塞性肺疾病易感性与ADAM33基因多态性的关系
- Author:
Shasha WANG
;
Jian GUAN
;
Shan WANG
;
Fangjuan CHENG
;
Xia REN
;
Xilin XU
;
Yan GAO
- Publication Type:Journal Article
- Keywords:
pulmonary disease,chronic obstructive;
ADAM proteins;
polymorphism,single nucleotide;
KAZAKH NA-TIONALITY;
ADAM33 gene;
haplotype
- From:
Tianjin Medical Journal
2015;(12):1349-1352,1353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore correlation of Xinjiang Kazakh population who suffered from COPD with polymor?phisms of F+1,S2,T1,ST+5 locus of ADAM33 gene. Methods Blood samples (n=193) from healthy controls (Control group, n=193) and COPD patients (Case group, n=197) were detected by SNP SNaP shot. Results Comparing case group with the control group, gene frequency and allele frequency of F+1 locus were of significant differences (P<0.05). In patient group, there were no significant differences in F+1 locus genotype and in clinical indicators include lung function FEV1 predicted and FEV1/FVC (P>0.05). The gene frequencies and allele frequency of S2、T1 and ST+5 locus were not significantly differ?ent between case group and control group (P>0.05). F+1 and S2 locus were analyzed by haplotype analysis which showed that there was significant differences in Hap1 (CC) haplotype between case group and control group (P<0.05), and OR<1 indicated that its haplotype may reduce the risk of COPD . There were significant differences (P<0.05) in Hap3(TC) haplo?type between case group and control group and OR>1 revealed that its haplotype may increase the risk of COPD . The distri?bution of Hap2 (TG) and Hap4 (CG) were not significantly different (P>0.05) between the 2 groups. T1 and ST+5 locus were analyzed by haplotype analysis which showed significant differences in haplotypes between case group and control group (P<0.05). Conclusion The occurrence of COPD may be related to the polymorphism of ADAM33 gene in F+1 locus in Xinjiang Kazakh.
