Expression of thymidine kinase 1 in primary hepatic carcinoma and its value in prognostic prediction
10.3969/j.issn.1006-5725.2016.03.015
- VernacularTitle:细胞质胸苷激酶1在原发性肝癌中的表达及其对预后的临床意义
- Author:
Weibo BO
;
Jibao QIN
;
Haiying LI
;
Xiaojuan FENG
;
Huiyi WU
- Publication Type:Journal Article
- Keywords:
Primary hepatic carcinoma;
Thymidine kinase 1;
Prognosis
- From:
The Journal of Practical Medicine
2016;32(3):396-398,399
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of TK1 (thymidine kinase 1) in PHC (primary hepatic carcinoma). Methods TK1 and AFP in serum of 33 cases of PHC (primary hepatic carcinoma), 38 cases of hepatic cirrhosis,36 cases of hepatitis and 35 cases of healthy people were detected by means of Western blot—enhanced chemiluminecence and electrochemiluminescence. Results The difference of TK1 level in PHC group indicated significance when compared with that in hepatic cirrhosis group , hepatitis group and control group (U value was 436.4, 352.1, 163.6, respectively, all P < 0.01). TK1 level in patients with PHC was related with differentiation (χ2 = 7.476,P < 0.05) and TNM stage (χ2 = 7.227,P < 0.05),but not with sex, age, tumor diameter, number of tumors, vascular invasion, lymph node metastasis (P > 0.05). Kaplan-Meier curve analysis revealed that PHC patients with TK1≤ 2.0 pmol/L had a significantly shortened overall survival when compared with those with TK1 > 2.0 pmol/L (χ2 = 3.954,P < 0.05). Multivariable Cox regression analysis indicated that the level of TK1 and TNM stage were the independent risk factors for patients with PHC (all P <0.05). Conclusions The detection of TK1 has a certain clinical value in the diagnosis, monitoring and evaluation of the prognosis of the PHC.
