Alcoholic liver disease：gut microbiota and therapeutic perspectives
10.3969/j.issn.1001-1978.2016.04.002
- VernacularTitle:肠道菌群失调介导酒精性肝病发生发展的机制研究进展
- Author:
Yue ZANG
;
Sheng WANG
;
Nan LIU
;
Li LIU
;
Qibing MEI
- Publication Type:Journal Article
- Keywords:
intestinal flora;
alcoholic liver disease;
bacterial translocation;
pro-inflammatory cytokines;
immune response;
probiotics
- From:
Chinese Pharmacological Bulletin
2016;32(4):451-454,455
- CountryChina
- Language:Chinese
-
Abstract:
Alcoholic liver disease ( ALD ) , a chronic progres-sive disease, threatens human health seriously. An increasing number of studies have shown that gut flora dysbiosis plays an important role in the development of ALD. Intestinal microbiota maintains a steady state under normal conditions, regulating gut flora normal physiological function. However, chronic alcohol consumption produces intestinal bacteria overgrowth and dysbio-sis, including the alteration of the composition of intestinal mi-croflora, the increment of gut permeability and bacterial translo-cation. Subsequently, the host immune is activated, promoting the production of inflammatory cytokines in liver, which plays a central role in the development of ALD. Notably, the supple-ment of prebiotics or probiotics reverses the intestinal flora disor-der,ameliorating the clinical symptoms effectively in ALD pa-tients. The evidence impies that the modulation of dysbiosis may be effective in the prevention and treatment of ALD. This review summarizes the research progress on the mechanism of the devel-opment of dysbiosis-mediated ALD, to provide a theoretical basis for the research on intestinal flora and ALD.
