Research progress of a new oncotherapy target TRAP1

VernacularTitle:肿瘤治疗新靶点TRAP1研究进展
Author: Peiliang SHEN ; Zhaoguo LIU ; Lihua SUN ; Xu WANG ; Ying SHEN ; Hongyan WU ; Aiyun WANG ; Yin LU
Publication Type:Journal Article
Keywords: TRAP1; AMPK; tumor; abnormal expression; mo-lecular mechanisms; clinical treatment
From: Chinese Pharmacological Bulletin 2016;32(4):459-462,463
CountryChina
Language:Chinese
Abstract: Tumor necrosis factor receptor-associated protein 1 (TRAP1),as one of the main members of the heat shock protein 90 family, resists oxidative stress-induced apoptosis as well as predominantly maintains the integrity of mitochondria and cellu-lar homeostasis. Abnormal expression of TRAP1 was herein closely related to the onset and progression of a wide variety of tumors. As a key regulatory factor mediating energy metabolism within tumor cells, TRAP1 may be able to kill them by interfer-ing with such metabolism. More importantly, the abnormal ex-pression of TRAP1 played a less important role in normal cells, allowing TRAP1 to be a particularly attractive target as it can be used in tumor treatment or interference. The relationship be-tween abnormal expression of TRAP1 protein and tumor onset was reviewed. Besides, the mechanism by which disordered TRAP1 protein expression induced tumor formation was postula-ted, which may provide references for future research and clini-cal treatment.