A study of 3D-PCASL in brain gliomas at 3.0T MR
10.3969/j.issn.1002-1671.2016.03.030
- VernacularTitle:3.0TMR3D-PCASL技术在脑胶质瘤微灌注研究
- Author:
Haibo LIAO
;
Xinlan XIAO
;
Zhongqiang DAI
;
Zhenghua LIU
;
Jianhua YU
;
Zhiqiang WANG
;
Wenjing JIN
;
Lei WU
;
Xiaoli SHEN
;
Jianhua WANG
- Publication Type:Journal Article
- Keywords:
3 dimensional pseudo-continuous arterial spin labeling;
gliomas;
microenvironment perfusion;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2016;32(3):441-444,451
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of 3D-PCASL in the pre-operation brain gliomas-grading.Methods 3D-PCASL images of 41 cases of gliomas comfirmed by pathology,including 20 cases of low-grade and 21 cases of high-grade were retrospectively analyzed. The cerebral blood flows of the solid region of tumor (TBF),1cm and 1 cm-2 cm brain tissue around the tumor,and contralateral normal brain CBF were obtained based on the region of interest (ROI),respectively.Results According to independent sample t-test,all had statisti-cally significant differences (P <0.001)between high and low-grade gliomas except the 1-2 cm region around the tumor.One-way ANO-VA displayed that all of them had its statistically significant between differences region (P <0.001)in high-grade gliomas,which had statisti-cally significant differences (P <0.001)except 1 cm and 1 -2 cm of peri-tumor in low-grade gliomas.ROC curve analysis of TBF/contralateral gray matter showed that the area under the curve was 0.96.When 2 was chosen as threshold of rCBF,there was the highest sensitivity (85.7%)and specificity (100%).The accurate rate of conventional MRI for gliomas dianosis was 76% and the ac-curate rate of conventional MRI with ASL was 93%,which was statistically significant difference (χ2 =6.61,P =0.01)between two methodson the chi-square test.Conclusion 3D-PCASL can improve the accuracy of diagnosis of different grade brain gliomas.Com-pared with others parameters,rCBF have a higher sensitivity and specificity.
