The study on the levels of serum uric acid in patients with bipolar disorder
10.3969/j.issn.1002-0152.2016.01.006
- VernacularTitle:双相情感障碍血清尿酸水平研究
- Author:
Hongmei CHEN
;
Jingxu CHEN
;
Dachun CHEN
;
Shuangjiang ZHOU
;
Ligang ZHANG
;
Xuan WANG
;
Chenghua TIAN
;
Shaoli WANG
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Depression;
Uric acid Hyperuricemia
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(1):29-33,44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of uric acid (UA) in bipolar disorder patients and their clini?cal significance. Methods Serum levels of UA was measured in 126 bipolar disorder patients including 77 mania pa?tients and 49 depression patients, 69 first-episode schizophrenic patients and 126 healthy controls (control group). Bipo?lar disorder patients was assessed by using the Young Mania Rating Scale (YMRS) and the Hamilton Depression Scale (HAMD). Results The serum UA levels were significantly higher in bipolar group [(349.34 ± 107.21) μmol/L] than in schizophrenic group [(319.71±84.48)μmol/L] and in control group [(280.94±71.90)μmol/L] (P<0.01). There were signifi?cant differences in serum UA levels between manic episode and depressive episode [(366.45 ± 104.01) μmol/L vs. (322.45±107.69)μmol/L]. The serum UA levels were higher in both manic episode and depressive episode groups than in control group (P<0.01). The serum UA levels was not significantly different between patients with and without medication (P>0.05). Correlation analysis indicated that the correlation of serum UA levels with YMRS scores and HAMD scores was not significant in bipolar disorder patients (P>0.05). Conclusions Patients with bipolar disorder has elevated serum uric acid levels which may be a biomarkers of bipolar disorder.
