"Train of Four" Response to Intravenous Suceinylcholine Chloride in Rabbits .
10.4097/kjae.1979.12.2.134
- Author:
Se Ung CHON
1
;
Young Moon HAN
;
Jee Sop YOO
Author Information
1. Department of Anesthesiology, Catholic Medical College, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Depression;
Hand;
Injections, Intravenous;
Knee;
Methods;
Muscles;
Neuromuscular Blockade;
Peroneal Nerve;
Rabbits*;
Succinylcholine
- From:Korean Journal of Anesthesiology
1979;12(2):134-139
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The history of muscle relaxants is fascinating, and their use for clinical applications has been accepted. Depolarizing drugs can produce a non-depolarizing type of neuromuscular block. Decamethonium produces a nondepolarizing block in the isolated rabbit lumbrical muscle. Electromyographic studies of the hand muscles in man have demonstrated that a dual block will be produced with doses of succinylcholine varying from 500 to 1,500 mg (initially a delpolarizing block and subsequently a non-depolarizing block exists). The common peroneal nerve in the rabbit knee was stimulated by a "train of four" method (Ali et al) repeated intermittently. The muscle response with the "train of four" method to intravenous succinylcholine chloride (1 mg/kg) in the rabbit was recorded and analysed after a single injection and repeated intravenous injections of succinylcholine chloride 1 mg/kg. Result were as follows: 1) Time after the "train of four" to depression of muscle twiteh of 25, 50, 75 & 100% was 128. 2, 135. 3, 142. 8 and 159 seconds respectively. 2) Recovery index of a single intravenous injection of succinylcholine chloride 1 mg/kg was observed as 3 minutes and 14 seconds. 3) A depolarizing form of "train of four" response to the first succinylcholine chloride injection 1 mg/kg was observed and, a non-depolarizing form of "train of four" response to the second dose of succinylcholine chloride 1 mg/kg was observed definitely.
