Comparison of the effect of different dose of omeprazole in the treatment of chronic gastric ulcer
10.3760/cma.j.issn.1008-6706.2016.01.024
- VernacularTitle:不同剂量奥美拉唑治疗慢性胃溃疡的效果比较
- Author:
Zhitian ZHOU
- Publication Type:Journal Article
- Keywords:
Stomach ulcer;
Omeprazole;
Dose -response Relationship,Drug
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;(1):85-87,88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the treatment effect of different dose of omeprazole in the treatment of chronic gastric ulcer.Methods 153 patients with gastric ulcer were selected as the research object,according to ran-dom number table.The patients were randomly divided into three groups,with each group of 51 cases.In the first three days,group A was given omeprazole 40mg added to 0.9% sodium chloride injection 20mL,intravenous drip,4 times/d. Group B was given omeprazole 40mg added to 0.9% sodium chloride injection 100mL,intravenous drip 2 times/d. Group C was given omeprazole 40mg added to 0.9% sodium chloride injection 100mL,intravenous drip 1 time /d. Then took omeprazole magnesium enteric -coated tablets oral,20mg/times,1 time /d.The treatment course was 4 weeks.The treatment effectiveness and adverse reactions were observed.Results The effective rates of 3 groups had significant difference(χ2 =11.573,P =0.003).The effective rate of group A was 98.3%,which was significantly higher than 84.3% of group B(χ2 =6.725,P =0.010)and 74.5% of group C(χ2 =11.922,P =0.001).The effec-tive rate of group B was higher than that of group C,but the difference was no statistically significant(χ2 =1.499,P =0.221).The patients of 3 groups had occasional headache,nausea,vomiting,fatigue,skin rashes and other adverse reactions,the symptom was lighter,there was no impact to the normal treatment.Conclusion In the first three days of the treatment,omeprazole added to 0.9% sodium chloride injection 20mL,intravenous drip,4 times/d,then taking omeprazole magnesium enteric -coated tablets oral to treat gastric ulcer has higher curative rate,less adverse reac-tion,the effect is better than that of middle and low doses of the drug,which has clinical value.
