Research progress on curcuma zedoary extracts inhibiting vascular smooth muscle cell proliferation in pathological process of in-stent restenosis
10.3969/j.issn.1001-1978.2016.01.005
- VernacularTitle:莪术提取物调控支架后再狭窄血管平滑肌细胞增殖的研究进展
- Author:
Huimin MAO
;
Jiangang LIU
;
Fuhai ZHAO
;
Dazhuo SHI
;
Xiuhua LIU
- Publication Type:Journal Article
- Keywords:
in-stent restenosis;
vascular smooth muscle cell;
curcuma zedoary;
proliferation;
molecular mechanisms;
curcu-min
- From:
Chinese Pharmacological Bulletin
2016;(1):19-21,22
- CountryChina
- Language:Chinese
-
Abstract:
Vascular smooth muscle cells (VSMCs) proliferation is the critical pathological process of in-stent restenosis (ISR). Recent researches indicate that the traditional Chinese medicine curcuma zedoary (E’zhu) can inhibit VSMCs proliferation, with a potential value in preventing and treating ISR. The major ac-tive components of curcuma zedoary are curcuma and β-elemene. The underlying mechanisms involve the inhibition of hemeoxygen-ase-1 expression, blockade of extracellular signal-regulated ki-nase – MAPK and Akt pathways, and subsequent cell cycle ar-rest. This article reviews the recent progress on curcuma zedoary extracts regulating VSMCs proliferation in ISR.
