On antipsychotic effects of l-Scoulerine
10.3969/j.issn.1001-1978.2016.01.022
- VernacularTitle:左旋金黄紫堇碱抗精神分裂症作用研究
- Author:
Yunyun GAO
;
Guiyun MI
;
Shuai LIU
;
Zheng YANG
- Publication Type:Journal Article
- Keywords:
schizophrenia;
l-SLR;
MK-801;
positive symptoms;
negative symptoms;
cognitive impairment;
extrapyramidal system
- From:
Chinese Pharmacological Bulletin
2016;(1):103-108,109
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the antipsychotic effects of l-Scoulerine ( l-SLR) . Methods NMDAreceptorantag-onist MK-801 was used to induce the positive and neg-ative symptoms of schizophrenia and cognitive impair-ment in animal models. The effects of l-SLR were eval-uated on schizophrenia induced by MK-801 and on ex-trapyramidal system. Results l-SLR (10,15 mg · kg - 1 , ip) could suppress pre-pulse inhibition damage in rats induced by MK-801 (0. 3 mg·kg - 1 , ip); l-SLR(30 mg·kg - 1 , ip) could inhibit climbing behav-iors in mice induced by apomorphine, which suggested that l-SLR had significant inhibiting effects on the posi-tive symptoms of schizophrenia by MK-801 and apo-morphine. l-SLR could also induce social contact inhi-bition and cognitive impairment induced by MK-801 (0. 2 mg · kg - 1 , ip), which proposed that l-SLR could improve the negative symptoms and cognitive im-pairment by MK-801. Catalepsy in mice could be caused by the treatment dose of haloperidol (0. 8 mg· kg - 1 , ip), not by that of l-SLR(30 mg·kg - 1 , ip). Conclusion I-SLR has significant effects on the posi-tive and negative symptoms of schizophrenia and cogni-tive impairment and, the effect of l-SLR under effective dose on extrapyramidal system is obviously much less than that of haloperidol and l-SPD.
