Effect of trepibutone tablet combined with ursodeoxycholic acid in treatment of patients with gallstone
- VernacularTitle:曲匹布通片联合熊去氧胆酸对胆囊结石患者的疗效
- Author:
Xinghai WANG
;
Minglei YANG
;
Zheng ZHOU
;
Weijie REN
;
Kai ZHAO
;
Sufen HUANG
- Publication Type:Journal Article
- Keywords:
trepibutone tablet;
ursodeoxycholic acid;
drug combination;
gallstone
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):120-121,124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of trepibutone tablet combined with ursodeoxycholic acid in treatment of patients with gallstone. Methods 200 cases with gallstone were diagnosed and randomly divided into observation group and control group from February 2013 to February 2014.100 cases in control group were given ursodeoxycholic acid treatment 50 mg/(kg? d),two times per day for six month.On the basis of control group observation group were treated with trepibutone one tablet per day,three times per day,4 weeks for 1 course, 2 weeks of treatment interval between 4 courses, totally for four courses.After treatment, patients were followed up and recorded gallbladder wall thickness, gallbladder functional status. Results After 6 months of treatment in patients with gallbladder wall thickness of observation group ( 2.77 ±0.38 ) mm was superior to control group (3.24 ±0.36)mm(P<0.05).After 6 months of treatment in patients with gallbladder function score of observation group (58.75 ±4.79) was better than control group (53.11 ±5.02) ( P<0.05).Recurrence rate of observation group was 9% better than that of control group 18%(χ2 =3.468,P<0.05)after treatment for 6 months.Conclusion Effect of trepibutone tablet combined with ursodeoxycholic acid in treatment of patients with gallstone is well.There is no obvious side effects during the treatment.
