Efficacy of atorvastatin combined with neuroendocrine antagonist in chronic heart failure
- VernacularTitle:阿托伐他汀联合神经内分泌拮抗剂治疗慢性心衰的疗效观察
- Author:
Zhongping SHI
;
Jiafeng LIN
- Publication Type:Journal Article
- Keywords:
atorvastatin;
neuroendocrine antagonist;
chronic heart failure;
combination
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):143-144,147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of atorvastatin combined with neuroendocrine antagonist in the treatment of chronic heart failure.Methods 70 patients of Wenzhou Medical College Theorem Clinical College of Cardiology Department from March 2014 to March 2015 were randomly divided into observation group and control group of 35 cases in each group.The control group were given the neuroendocrine antagonist, observation group were given atorvastatin combined with neuroendocrine antagonist treatment. The changes of related indicators were recorded. Results The aminoterminal pro-brain natriuretic peptide (NT-ProBNP) and ejection fraction in observation group were [(1264.7 ±174.6)pg/mL, (0.58 ±0.07)], which were higher than those in control group [(2106.5 ±164.8)pg/mL,(0.49 ±0.08)](P<0.05).The total effective rate in observation group was 91.43%, which was higher than 71.43%in control group(P<0.05).Conclusion Atorvastatin joint neuroendocrine antagonist in treatment of chronic heart failure has clinical exact effect with no significant side effects.
