Effect of ligustrazine injection combined with chemotherapy on IL-1, IL-4 and TGF-βin patients with advanced hepatocellular carcinoma
- VernacularTitle:川芎嗪注射液联合化疗对晚期肝癌患者 IL－1、IL－4及TGF－β的影响
- Author:
Yanling XU
;
Zhuodong LI
;
Fengyan TANG
;
Yizhou TIAN
;
Wenbin CHEN
- Publication Type:Journal Article
- Keywords:
ligustrazine injection;
advanced hepatocellular carcinomar;
combined chemotherapy;
immunological parameters
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):153-154,157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of ligustrazine injection combined with chemotherapy on common immunological parameters in patients with advanced hepatocellular carcinoma.Methods Eighty cases diagnosed with advanced hepatocellular carcinoma from January 2013 to January 2015 in the hospital were randomly divided into observation group and control group, 40 patients in each group.The control group received only conventional treatment of chemotherapy and observation group received ligustrazine injection on the basis of control group.The levels of interleukin-1 (IL-1), IL-4 and transforming growth factor beta ( TGF-β) wwere compared based on the record between two groups pre-and post-treatment.Results There were no significant differences between two groups in IL-1,IL-4 and TGF-βlevels pre-treatment.After treatment, the IL-1, IL-4 and TGF-βlevels in observation group were lower than those in control group [(41.4 ±11.8)vs (76.0 ±12.2)ng/L,(118.5 ±39.9)vs(223.0 ±47.3)ng/L,(6.7 ±3.2)vs(11.7 ± 2.6)ng/mL, respectively, all P<0.05].Conclusion Ligustrazine injection combined with chemotherapy has an exact effect on improving the immunological parameters associated with advanced hepatocellular carcinoma without significantly increasing side effects, it is worthy of further research and application.
