Clinical observation of tirofiban on myocardial protection of surgical coronary intervention
- VernacularTitle:替罗非班对冠状动脉介入手术心肌保护作用的临床效果观察
- Author:
Jie XIAO
;
Lan WANG
;
Ye GU
;
Xiaoyang ZHOU
- Publication Type:Journal Article
- Keywords:
different loading dose;
tirofiban;
acute myocardial infarction
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):49-50,53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of different doses of tirofiban for PCI, myocardial injury and arterial flow conditions.Methods 70 patients undergoing PCI elevation acute myocardial infarction, were randomly and equally divided into the observation group and the control group.The control group of patients before PCI given haplotype character loading dose of tirofiban, the observation group were given a double load before PCI tirofiban.Recording and analyzing two groups of patients cTnI (cardiac troponin I), 90 minST section down percentage circumstances.Results The patients after 6h, 12h, 24hcTnI contents were (2.11 ±0.50,3.50 ±1.64,3.28 ±1.15) ng/mL was significantly lower than the control group (4.09 ± 1.13,9.48 ±2.61,5.79 ±1.26) ng/mL, and the difference was significant(P<0.05); the observation group were CTFC, 90 min fall within ST respectively was significantly better than the control group ( P<0.05 ) .Conclusion Preoperative use of double loading dose of tirofiban can effectively improve the blood flow after PCI,, and reduce the incidence of myocardial injury and postoperative cardiovascular events.
