The Clinicopathological and Prognostic Significance of α-catulin Expression in Head Neck Squamous Cell Cancers
- VernacularTitle:头颈部鳞癌中α-catulin表达的临床病理和预后意义
- Author:
Bo QIU
;
Zhuo ZHANG
;
Daofu SHEN
;
Xuefeng YANG
;
Huachuan ZHENG
;
Yasuo TAKANO
;
Keqiang HUANG
- Publication Type:Journal Article
- Keywords:
head and neck squamous cell carcinoma;
α-catulin;
pathogenesis;
progression;
prognosis
- From:
Journal of China Medical University
2015;(12):1079-1082,1086
- CountryChina
- Language:Chinese
-
Abstract:
Objective Rho signaling component α-catulin,is a cytoskeletal linker protein and plays an important role in apoptotic and senescence resistance,cytoskeletal reorganization,mobility,invasion and epithelial to mesenchymal transition(EMt)of cancer cells. Methods Here,we ex-amined α-catulin expression in squamous epithelium,dysplasia and cancer of head and neck on tissue microarrays by immunostaining. Its expres-sion was compared with clinicopathological parameters and survival rate of cancers. Results It was found that α-catulin expression level was signifi-cantly higher in primary cancers than that in normal squamous epithelium and dysplasia(P < 0.05),but not significantly correlated with aggressive behaviors or adverse prognosis of HNSCC patients(P > 0.05). Cox′s proportional hazard model indicated that distant metastasis and tNM staging were independent prognostic factors for overall survival of the patients with head and neck squamous carcinoma(HNSCC,P < 0.05). Conclusion these findings suggested that up-regulated expression of α-catulin protein may play an important role in the pathogenesis of HNSCC,which might be employed as a potential marker for tumorgenesis of HNSCCs.
