Clinical study of glucose tolerance with Cushing's syndrome

VernacularTitle:库欣综合征患者糖代谢临床分析
Author: Jing LI ; Guijun QIN ; Chenzhao DING ; Tianxue ZHAO ; Hao YUE
Publication Type:Journal Article
Keywords: Cushing's syndrome; Diabetes; Impaired glucose tolerance ( IGT)
From: Chinese Journal of Endocrine Surgery 2015;(6):458-460,467
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical data of patients with Cushing's syndrome(CS)and to un-derstand the relationship between glucose metabolism and CS .Methods Oral glucose tolerance test (OGTT), the level of insulin, body mass index(BMI), 24-hour urinary free cortisol(24h UFC), family history of diabetes in patients with CS were retrospectively analyzed .Results The course of disease in patients of CS complicated with diabetes mellitus ( CS/DM) group was longer than CS complicated with impaired glucose tolerance ( CS/IGT) and CS complicated with normal glucose tolerance (CS/NGT)group.66.67%of patients with CS/NGT have insu-lin resistance .Logistic regression analysis indicated that age , course of disease , midnight plasma cortisol were risk factors of CS induced diabetes mellitus .CS/DM group had higher proportion of family history of diabetes . 24h UFC and BMI had no significant differences among the three groups (P>0.05).Conclusions Age, course of disease , midnight plasma cortisol are risk factors of CS induced diabetes mellitus .OGTT and insulin level de-termination are necessary for diagnosis and intervention treatment at the early stage .