Research on protein expression of CD55 in triple-negative breast cancer and its effect on prognosis
10.3969/J.ISSN.1672-8270.2015.12.013
- VernacularTitle:促衰变因子在三阴性乳腺癌中的表达及其对预后的影响
- Author:
Tiejun LI
;
Haiyan ZHANG
;
Wei JIANG
- Publication Type:Journal Article
- Keywords:
Triple-negative breast cancer;
Decay accelerating factor;
Immunohistochemistry;
Prognosis
- From:
China Medical Equipment
2015;(12):41-43,44
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of CD55 in triple-negative breast cancer (TNBC) and its correlations with prognosis.Methods: The expressions of CD55 was detected by immunohistochemistry Streptavidin-Peroxidase method in 100 cases of triple-negative breast cancer and 50 cases of adjacent-carcinoma tissues, with clinical and pathological features and follow-up data, the Cox model analysis was established and to analyze the prognostic factors. Results: The positive expression of CD55 was 56.0% in the tissues from triple-negative breast cancer, whereas its positive rate was 8.0% in the corresponding adjacent breast tissues, with statistical significance (x2=32.0,P<0.05). The expression of CD55 was significantly related with tumor size, clinical stage and axillary lymph node metastases (x2=7.404,x2=8.688,x2=4.802;P<0.05); the expression of CD55 did not show correlation to age, and histologic grade. Multivariate analysis showed that the age, clinical stage, CD55 protein expression and axillary lymph node metastasis were the independent risk factors affecting the 5-year disease-free rate of patients and that clinical stage and axillary lymph node metastasis were the independent risk factors affecting the 5-year overall rate of patients.Conclusion: The expression of CD55 might be related to the development and prognosis of triple-negative breast cancer. The expression of CD55 may be used as one of the indicators in determining the progress and prognosis of TNBC.
