Evaluation on rapid ELISA method in detecting D-dimer combined with cardiac troponin I for early exclusion of myocardial infarction
10.3969/j.issn.1673-4130.2015.24.033
- VernacularTitle:快速ELISA 法检测D-二聚体结合肌钙蛋白I用于早期排除心肌梗死的评价
- Author:
Wei ZHAO
;
Jian SU
- Publication Type:Journal Article
- Keywords:
cardiac troponin I;
D-dimer;
acute myocardial infarction
- From:
International Journal of Laboratory Medicine
2015;(24):3586-3587,3590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of rapid ELISA method in detecting D‐dimer combined with cardiac tro‐ponin I (cTnI) for early exclusion of acute myocardial infarction (AMI) .Methods The samples from 178 consecutive patients with chest pain and suspected AMI were tested for cTnI and D‐dimer on admission;then cTnI was also tested at 6 h after admission . AMI was definitely diagnosed by echocardiography combined with angiography .The cTnI cut‐off for diagnosing AMI was 0 .11μg/L (accounting for 10% of total CV lowest level) .Results AMI was diagnosed in 40 cases(22 .4% ) .The negative prediction value (NPV) on admission was 87 .9% for single cTnI and increased to 98 .4% at 6 h after admission .The cut‐off for single D‐dimer on admission was 200 ng/mL FEU and its NPV was 87 .9% .No false negative was observed when both cTnI and D‐dimer were nega‐tive on admission .Conclusion The combination detection of cTnI and D‐dimer has the potential to be used as an early exclusion di‐agnosis of suspected AMI in the patients with chest pain at arriving in the emergency department ,thus shorten the patient′s hospi‐tal duration and save costs .
